effrightscorp t1_jegevz4 wrote
Reply to comment by shockencock in ELI5: If benzodiazepines are CNS depressants, why is it so hard to die from a overdose of them alone? by psychrolute
50 mg lorazepam won't even kill a rat
shockencock t1_jegf1ja wrote
You have it confused with another benzo. 50 mg of lorazepam will kill you in about an hour
effrightscorp t1_jegfzyj wrote
LD50 is 1850 mg/kg in mice, so it takes around 40 mg to kill an average one. Here's a case study where one guy took 100 mg, one woman took 120 mg and both were out of the hospital within a few days and didn't really need any treatment
You can take stupid big overdoses of benzos and survive because they all have pretty good therapeutic indices. The bigger issue is that, if you don't pass out, you'll probably run out blacked out and can do enough stupid shit to end up in jail etc
shockencock t1_jegfcqz wrote
My brother is a psychiatric nurse in a hospital. He would inject 2 mg of lorazepam into patients then put them into seclusion to sleep it off. The starting dose for lorazepam is like .5 mg
effrightscorp t1_jeggc1l wrote
That says nothing about the lethal dose, which is much higher than 50 mg in humans
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