j_ohnsonson t1_jegr22o wrote on March 31, 2023 at 10:09 PM

Reply to comment by anvuu in ELI5: If benzodiazepines are CNS depressants, why is it so hard to die from a overdose of them alone? by psychrolute

I believe that Is tied to the fact that when a status epilepticus goes on for some time, the GABA receptors start being pulled away (in a process called endocytosis) from the synapses. So You Need to rely on drugs that use other mechanisms to get the neurons to stop firing. Happy to be corrected if someone has more up to date or precise info