Benzos have a limit to their function. They depend on a neurotransmitter called GABA which is a CNS depressant. Once GABA is depleted then any additional Benzos will have no effect, therefore no overdose. Unfortunately, if you compound this effect with other depressants (who operate on a different mechanism) you can get respiratory depression which can be fatal.
SkyARKy t1_jef4h4o wrote
Reply to ELI5: If benzodiazepines are CNS depressants, why is it so hard to die from a overdose of them alone? by psychrolute
Benzos have a limit to their function. They depend on a neurotransmitter called GABA which is a CNS depressant. Once GABA is depleted then any additional Benzos will have no effect, therefore no overdose. Unfortunately, if you compound this effect with other depressants (who operate on a different mechanism) you can get respiratory depression which can be fatal.