d0rf47 t1_jefzmsx wrote

its likely that the effects of one are potentiating the effects of the other. The bigger issue is a persons response to the drug and how their body metabolizes it. I am not a physician just some with a keen interest in pharmacology. CNS is your central nervous system, this system control much more than just breathing, certain drugs may affect the heart more while others affect the breathing more. the issue becomes troubling when the cns is suppressed enough that one of sub systems (breathing or heart) becomes so low that it either stop functioning and arrest begins or in some cases it may be that they are both still "functioning" but not properly and hypoxia can set in. My understanding with GHB and alcohol is that its the heart rate dropping which causes the dangerous effect.


d0rf47 t1_jefphrh wrote

The reason is these types of drugs (GHB and ethanol) both interact with your brains GABA system which is the bodys inhibitory neurotransmitter. Your body uses it to essentially calm itself. This also has effects on heart rate and respiration. this is why they are dangerous. Since the both activate this system they essentially relax your body to the point where your heart can stop pumping(cardiac arrest) or your lungs stop functioning on their own (respiratory arrest)


Other "depressant" drugs also have dangerous interactions since the systems they work on can also have similar effects on the same systems even though they work using different neurotransmitters, eg being heroin and alcohol. They activate different systems in the body, however these systems have similar effects such as decreased heart rate & lowered respiration. which is why they can also be a dangerous combination.


This is also the reason these drugs are so physically addictive and cause dangerous withdrawl symptom. Since they work with such critical natural bodily responses, when you get dependent on them your body stops operating these systems normally and when the chemical substitute (let say alcohol in the example) is no longer present/available the system goes haywire since the body is no longer capable of regulating the system which is why ppl can suffer strokes or heart attacks if they attempt to detox without medical supervisions.


d0rf47 t1_iy959up wrote

this is a false premise. The reality is actually based on resource allocation in most cases especially in tech. Typically companies will allocate a larger pool of resources for hiring then they do for raises. Not sure exactly why but this is becoming more and more common


d0rf47 t1_itvsmob wrote

Heres a better LPT: Live your life and don't be defined by what you do for work. If you look to your job for fulfillment you will be left empty. There are some very very rare exceptions to this.